It is highly optimized and uses the LuaVoxelManipulator.
It also has some effects, including randomness and particles, and is easily configurable.
The mese nuke has a range of 24 by default, and takes approximately 0.7 seconds to detonate with a full area. However I've managed to make an explosion with a radius of 128 (256x256x256) in about a minute (see screenshots below).
It stores configuration in nuke.conf in the world directory (see README.md) and is usable on servers, due to it's optional privilege requirements.
Note that the missile is currently very unpolished, due to limitations of the core.
Note that the explosives also don't drop items, for speed.
Texture licences: CC-BY-SA 4.0 by ShadowNinja, and CC-BY-SA 3.0 by sfan5
Missile model and texture license: WTFPL by Jordach
Sound license: Unknown